Deficiency of Vitamin B12-Binding Alpha Globulin in Two Brothers
نویسندگان
چکیده
منابع مشابه
Deficiency of vitamin B12-binding alpha globulin in two brothers.
E NDOGENOUS VITAMIN B12 circulates bound to an alpha-i glycoprotein.”2 Added vitamin binds primarily to a globulin with beta mobility electrophoretically, which may serve mainly a temporary transport function.3’4 This beta globulin readily gives up its vitamin B12 to cells, while the alpha globulin seems to serve as a circulating storage depot.3’5’6 With the exception of some conditions involvi...
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Functional vitamin B12 deficiency is a syndrome where a wide variety of symptoms in the presence of “normal” serum levels of the vitamin respond to vitamin B12 therapy. A series of patients with functional vitamin B12 deficiency are described whose presenting features were drenching night sweats and fatigue. Reliance on serum vitamin B12 levels as a diagnostic test would have obscured the cause...
متن کاملVitamin B12 deficiency.
Patients with subacute combined degeneration who smoked had significantly lowered plasma thiocyanate levels than control smokers, but plasma thiocyanate levels in non-smoking patients with neurological disease due to vitamin B1, deficiency were not significantly different from control values. The results provide no support for the hypothesis that chronic cyanide intoxication is responsible for ...
متن کاملVitamin B12 deficiency.
Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK Correspondence to: A Hunt [email protected] Cite this as: BMJ 2014;349:g5226 doi: 10.1136/bmj.g5226 Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious c...
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Metformin is an invaluable hypoglycaemic agent. We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of the cord or anaemia.
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ژورنال
عنوان ژورنال: Blood
سال: 1969
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v33.1.1.1